Making a boot-disk is by far the best way to get rid of the virus. The important thing is, of course, to make the disk on a non-infested PC. Just have a friend create a bootable medium, floppy or CDROM, plus a dos-runnable version of the most up-to-date virus-scanner you can find. Boot by removable medium, start up the virus-scanner and voila.
Of course, your virus scanner might just be out-dated. Most scanners (if not all) scan the memory and running processes, not just drivespace, so they should detect and kill the virus even if it's running. Have you updated it recently?
it's when you get a hard-on making Lassie a fatality!