i think this is maybe, too personal a question to ask, and i thought about that actually before i composed it, but it's like an unshakable sentimental mood
but what of people who seem to have a feeling of loss? that sounds close to separation anxiety, where it's not really the sense of loss of the mother that creates a void, but a realization of loneliness and vulnerability that causes panic, that sends the child into utter confusion and scare
also, closer to an idea of object permanence, where when you cover up something from view, it's still there in theory (or erwin schrodinger might actually argue against such a notion with a sense of dubiousness anyway), like a reference to the "out of sight, out of mind" remark, and this was idea was tested against infants who supposedly could not tell that an object was still there after covered up with a bowl
this latter concept could be related to your statement, that a sense of loss may be involved in meaning, but, does the item hold real meaning, or is it just that a separation from the item could suggest something else? the item in question may become part of the mind immediately, and the separation from it may make the self feel like a part of it has become severed
this does not necessarily mean the item itself held meaning but that it became established as part of the self's psyche, that produces the sense of loss
i know psychology (and theosophy or epistemology maybe) is no fun, but it's neat when people learn something about themselves without all the fuss of melodramatic epiphanies