It happens. I always reach out and if they answer, fantastic, if not, I see it as an unfortunate missed opportunity.
Regardless, just keep your head up. Someone will eventually answer back. I've only met one person on this forum(literally maybe a month ago) and had a blast with them. We've already become pretty good friends. And it's allowed me to feel more comfortable reaching out to people that I think may 1) be in the area as me and 2) down to meet up for coffee/tea or lunch and just talk. I think a session does so much better with the mindset that you KNOW the person a bit deeper than just a superficial "let me just tickle you and get my jollies off". I'm finding it so much more entertaining and enjoyable when I know they are actually having a good time with it!