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why do some people lose their ticklishness over time?

The primary cause seems to be 'natural neurodegeneration', which means that ppl's experience of the natural decrement of their neuro sensitivity throughout age.
Many ppl have become less & less sensitive to general sensations, including tickling sensation, throughout age.
It should be generally true, since older ppl are shown to be generally less ticklish than younger ppl based on scientific researches.
And the sensitivity (to tickling sensation) of some ppl may naturally degenerate to (almost) zero at certain ages.

The second but also important cause may be emotion/mood.
Some ppl may get increasingly negative emotion/mood toward being tickled, which can genuinely make them have less & less ticklish reactions over time.

The third reason may be that some ppl are good at getting used to tickling sensation throughout time.

You may read some posts in this thread of mine:
 
I believe so much of tickling is psychological. For me, it has increased overtime, but I think that is a direct result of engaging in therapy and putting in a lot of work around self acceptance and self love.

In doing so, I think I’ve been able to connect with my feelings, both physical and mental in a different way, and I’ve allowed myself to feel more vulnerable, which has led to feeling more ticklish in a session.

I think sometimes it might feel like it is going away because we don’t have the same physical opportunities, or because we are highly focused on stressors and anxieties, among other things.

Just my personal experience.
 
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