as a lee:
Fictional, live-action: Annie Edison (Community), Daenerys Targaryen (Game of Thrones)
Non-fictional: too many ;-)
as a ler:
Fictional, animated: Leela (Futurama)
Fictional, live action: Cersei Lannister (Gam of Thrones), Debra Morgan (Dexter)
Non-fictional: Cate Blanchett, Mila...