stacyshippen
TMF Poster
- Joined
- Nov 12, 2001
- Messages
- 112
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Hi all
I found this link on a web site devoted to opiates:
http://opioids.com/tickling/index.html
In adolescent rats, 50-kHz vocalizations are most evident during tickling and rough-and-tumble play. The following experiments evaluated whether 50-kHz vocalizations reflect positive social affect by determining (1) if tickling is a rewarding event, (2) if social or isolate housing conditions differentially influence the response (since housing condition has been found to effect the reward magnitude of social encounters), and (3) if drugs that work on mu-opiate receptors, which has been hypothesized to control positive social affect, modulate tickling. Tickling was positively reinforcing as demonstrated by elevated operant behavior, conditioned place preference, and approach measures. A significant negative correlation between vocalization rate and approach latency measures was found. Social housing reduced tickle-induced vocalizations and approach speeds compared to isolate housing. Naloxone (1 mg/kg) increased vocalization in the socially housed rats and decreased it in isolated Subjects (Ss). These findings suggest that tickling can be used to induce positive social affect in rodents, and that it is modulated by endogenous opioids.
You all think...HUH???
It took me several readings to get through it...but...there are two thoughts that I have...
...wouldn't it be great if someone applied this experiment to human beings? Maybe the answer to depression and antisocial behavior is a good, rollicking tickle fight, eh?
Where do I volunteer? 🙂
...I have no idea what Naloxone is...but I can't help but wonder if it makes the person more ticklish or just laugh harder? 🙂
Just another musing on a Friday...
Stacy
I found this link on a web site devoted to opiates:
http://opioids.com/tickling/index.html
In adolescent rats, 50-kHz vocalizations are most evident during tickling and rough-and-tumble play. The following experiments evaluated whether 50-kHz vocalizations reflect positive social affect by determining (1) if tickling is a rewarding event, (2) if social or isolate housing conditions differentially influence the response (since housing condition has been found to effect the reward magnitude of social encounters), and (3) if drugs that work on mu-opiate receptors, which has been hypothesized to control positive social affect, modulate tickling. Tickling was positively reinforcing as demonstrated by elevated operant behavior, conditioned place preference, and approach measures. A significant negative correlation between vocalization rate and approach latency measures was found. Social housing reduced tickle-induced vocalizations and approach speeds compared to isolate housing. Naloxone (1 mg/kg) increased vocalization in the socially housed rats and decreased it in isolated Subjects (Ss). These findings suggest that tickling can be used to induce positive social affect in rodents, and that it is modulated by endogenous opioids.
You all think...HUH???
It took me several readings to get through it...but...there are two thoughts that I have...
...wouldn't it be great if someone applied this experiment to human beings? Maybe the answer to depression and antisocial behavior is a good, rollicking tickle fight, eh?
Where do I volunteer? 🙂
...I have no idea what Naloxone is...but I can't help but wonder if it makes the person more ticklish or just laugh harder? 🙂
Just another musing on a Friday...
Stacy



